Detailed view for PF3D7_1414300

Basic information

TDR Targets ID: 2474
Plasmodium falciparum, 60S ribosomal protein L10, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.5143 | Length (AA): 219 | MW (Da): 25216 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00252   Ribosomal protein L16p/L10e

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 170 1vq8 (H) 1 168 34.00 0 1 1.04 0.13
4 172 1vq8 (H) 1 170 33.00 0 1 1.04709 0.05
40 176 2pa2 (A) 40 176 69.00 0 1 1.13357 0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_126951)

Species Accession Gene Product
Arabidopsis thaliana AT1G26910   60S ribosomal protein L10-2
Arabidopsis thaliana AT1G66580   60S ribosomal protein L10-3
Babesia bovis BBOV_III010500   ribosomal protein L10, putative
Brugia malayi Bm1_34250   60S ribosomal protein L10
Candida albicans CaO19.2935   likely cytosolic ribosomal protein similar to S. cerevisiae RPL10 (YLR075W) large subunit protein L10
Candida albicans CaO19.10452   likely cytosolic ribosomal protein similar to S. cerevisiae RPL10 (YLR075W) large subunit protein L10
Caenorhabditis elegans CELE_F10B5.1   Protein RPL-10
Cryptosporidium hominis Chro.60480   ribosomal protein L10
Cryptosporidium parvum cgd6_4190   60S ribosomal protein L10, alpha/beta hammerhead
Dictyostelium discoideum DDB_G0288273   S60 ribosomal protein L10
Drosophila melanogaster Dmel_CG17521   Ribosomal protein L10
Echinococcus granulosus EgrG_000094300   60S ribosomal protein L10
Entamoeba histolytica EHI_044810   ribosomal protein L10, putative
Entamoeba histolytica EHI_098780   ribosomal protein L10, putative
Entamoeba histolytica EHI_185010   ribosomal protein L10, putative
Echinococcus multilocularis EmuJ_000094300   60S ribosomal protein L10
Giardia lamblia GL50803_10428   Ribosomal protein L10
Homo sapiens ENSG00000165496   ribosomal protein L10-like
Homo sapiens ENSG00000147403   ribosomal protein L10
Leishmania braziliensis LbrM.04.0950   60S ribosomal protein L10, putative
Leishmania braziliensis LbrM.04.0740   60S ribosomal protein L10, putative
Leishmania donovani LdBPK_040750.1   60S ribosomal protein L10, putative
Leishmania infantum LinJ.04.0750   60S ribosomal protein L10, putative
Leishmania infantum LinJ.04.0950   60S ribosomal protein L10, putative
Leishmania major LmjF.04.0950   60S ribosomal protein L10, putative
Leishmania major LmjF.04.0750   60S ribosomal protein L10, putative
Leishmania mexicana LmxM.04.0950  
Loa Loa (eye worm) LOAG_04367   60S ribosomal protein L10
Mus musculus ENSMUSG00000008682   ribosomal protein L10
Mus musculus ENSMUSG00000060499   ribosomal protein L10-like
Mus musculus 434434   predicted gene 5621
Neospora caninum NCLIV_041180   60S ribosomal protein L10, related
Oryza sativa 4337928   Os05g0169100
Oryza sativa 4350098   Os11g0220800
Oryza sativa 4332737   Os03g0332500
Plasmodium berghei PBANKA_1028400   60S ribosomal protein L10, putative
Plasmodium falciparum PF3D7_1414300   60S ribosomal protein L10, putative
Plasmodium knowlesi PKNH_1343800   60S ribosomal protein L10, putative
Plasmodium vivax PVX_085735   60S ribosomal protein L10, putative
Plasmodium yoelii PY07431   Ribosomal L10, putative
Saccharomyces cerevisiae YLR075W   ribosomal 60S subunit protein L10
Schistosoma japonicum Sjp_0046280   ko:K02866 large subunit ribosomal protein L10e, putative
Schistosoma japonicum Sjp_0037300   60S ribosomal protein L10, putative
Schistosoma mansoni Smp_013200.2   60S ribosomal protein L10
Schistosoma mansoni Smp_013200.1   60S ribosomal protein L10
Schmidtea mediterranea mk4.020561.00   60S ribosomal protein L10
Schmidtea mediterranea mk4.000466.07   60S ribosomal protein L10
Schmidtea mediterranea mk4.000500.07   60S ribosomal protein L10
Schmidtea mediterranea mk4.032294.01   60S ribosomal protein L10
Schmidtea mediterranea mk4.003708.05   60S ribosomal protein L10
Schmidtea mediterranea mk4.001001.00   60S ribosomal protein L10
Trypanosoma brucei gambiense Tbg972.9.4600   60S ribosomal protein L10, putative,QM-like protein
Trypanosoma brucei gambiense Tbg972.9.4410   60S ribosomal protein L10, putative,QM-like protein
Trypanosoma brucei Tb927.9.8420   QM-like protein
Trypanosoma brucei Tb927.9.8070   QM-like protein
Trypanosoma congolense TcIL3000_9_2800   60S ribosomal protein L10, putative
Trypanosoma congolense TcIL3000_9_2910   60S ribosomal protein L10, putative
Trypanosoma cruzi TcCLB.510241.50   60S ribosomal protein L10, putative
Trypanosoma cruzi TcCLB.510243.40   60S ribosomal protein L10, putative
Trypanosoma cruzi TcCLB.510579.80   60S ribosomal protein L10, putative
Trypanosoma cruzi TcCLB.510575.190   60S ribosomal protein L10, putative
Toxoplasma gondii TGME49_288720   ribosomal protein RPL10
Theileria parva TP02_0093   60S ribosomal protein L10, putative
Trichomonas vaginalis TVAG_232820   60S ribosomal protein L10, putative
Trichomonas vaginalis TVAG_437020   50S ribosomal protein L10e, putative
Trichomonas vaginalis TVAG_291010   60S ribosomal protein L10, putative
Trichomonas vaginalis TVAG_074610   60S ribosomal protein L10, putative
Trichomonas vaginalis TVAG_407240   60S ribosomal protein L10, putative

Essentiality

PF3D7_1414300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.0110 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.0110 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.0110 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.0110 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.0340 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.0340 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.0340 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.0340 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F10B5.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F10B5.1 Caenorhabditis elegans larval arrest wormbase
CELE_F10B5.1 Caenorhabditis elegans slow growth wormbase
CELE_F10B5.1 Caenorhabditis elegans sterile wormbase
YLR075W Saccharomyces cerevisiae inviable yeastgenome
TGME49_288720 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1414300 (Plasmodium falciparum), 60S ribosomal protein L10, putative
Title for this comment
Comment